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Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin.
| Title | Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Weiss LA, Veenstra-Vanderweele J, Newman DL, Kim S-J, Dytch H, McPeek MSara, Cheng S, Ober C, Cook EH, Abney M |
| Journal | European journal of human genetics : EJHG |
| Volume | 12 |
| Pagination | 949-54 |
| Date Published | 11 |
| ISSN | 1018-4813 |
| Abstract | Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value = 9.8 x 10(-5)). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL. |
| DOI | 10.1038/sj.ejhg.5201239 |