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Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism.
| Title | Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Cross S, Kim S-J, Weiss LA, Delahanty RJ, Sutcliffe JS, Leventhal BL, Cook EH, Veenstra-Vanderweele J |
| Journal | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology |
| Volume | 33 |
| Pagination | 353-60 |
| Date Published | 1 |
| ISSN | 0893-133X |
| Abstract | {Elevated platelet serotonin (5-hydroxytryptamine, 5-HT) is found in a subset of children with autism and in some of their first-degree relatives. Indices of the platelet serotonin system, including whole blood 5-HT, 5-HT binding affinity for the serotonin transporter (K(m)), 5-HT uptake (V(max)), and lysergic acid diethylamide (LSD) receptor binding, were previously studied in 24 first-degree relatives of probands with autism, half of whom were selected for elevated whole blood 5-HT levels. All subjects were then genotyped for selected polymorphisms at the SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 loci. Previous studies allowed an a priori prediction of SLC6A4 haplotypes that separated the subjects into three groups that showed significantly different 5-HT binding affinity (K(m) |
| DOI | 10.1038/sj.npp.1301406 |